PQQ (Pyrroloquinoline Quinone or Methoxatin) Supplement Dosage

What Dosage of PQQ Supplement Should You Take?

Scientists and health professionals are still researching to find out the optimal dosage of PQQ (Pyrroloquinoline Quinone or Methoxatin) for best results. Animal studies have shown that even very small amounts of PQQ can support good health. In fact, as little as 200 to 300 nanograms of PQQ per gram of food were found to support optimal health in rodents. This is also roughly the concentration of PQQ found in human milk. For an adult human consuming 2000 to 3000 calories per day (i.e. about 400 to 500 grams of solid food per day), this translates into 0.1 to 0.15 milligrams of PQQ.

Most PQQ Supplements contain 10 Milligrams of PQQ - Why?

Most PQQ supplements on the market contain 10 milligrams of PQQ as a daily dose. While this might seem like a lot compared to the 0.1 to 0.15 milligrams estimated requirement, there are very good reasons for using 10 milligrams in supplements. First of all, the estimated 0.1 to 0.15 milligrams is the lowest amount estimated to be sufficient for good health. Second, it assumes that the diet consumed is very pure and bioavailable. When consuming normal foods, a higher amount will be needed. In addition, PQQ tends to break down easily and probably only a fraction of the consumed amount will reach the blood stream and exert its beneficial effects.

Based on these factors, the current recommendation for PQQ dosage from supplements is 10 mg per day. This dose is believed to confer the best benefits of PQQ. This dose is also backed by a number of clinical trials which have supplemented patients with 10 mg PQQ per day and observed health improvements such as lower plasma triglycerides and a reduced inflammatory state.

Which Supplements Work Well with PQQ?

It appears that combining PQQ supplements with some other supplements may enhance the benefits of these nutrients. Combining PQQ with resveratrol, quercetin and hydroxtyrosol may enhance the stimulation of mitochondrial function brought about by PQQ. CoQ10 and carnitine are also possibly synergistic with PQQ. As always, consult with your doctor before starting any new supplement including PQQ.

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